Lyophilization / Freeze Drying - An Review
نویسنده
چکیده
1 Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupathi, AP, India. 2 Faculty, Department of Pharmaceutics, OMER EL MUKHTAR University, Al-Beida, Libiya 3 Department of Pharmaceutical Chemistry, Shankarlingam Bhuvaneswari College of Pharmacy, Sivakasi, TN,India 4 Principal, Seven Hills College of Pharmacy, Tirupathi, AP, India 5 Research Director, Seven Hills College of Pharmacy, Tirupathi, AP, India
منابع مشابه
Freeze-drying process monitoring using a cold plasma ionization device.
A cold plasma ionization device has been designed to monitor freeze-drying processes in situ by monitoring lyophilization chamber moisture content. This plasma device, which consists of a probe that can be mounted directly on the lyophilization chamber, depends upon the ionization of nitrogen and water molecules using a radiofrequency generator and spectrometric signal collection. The study per...
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F reeze-drying or lyophilization is a process that removes water from a substance. This dehydration process is performed under vacuum while the substance is in a frozen state. Lyophilization technology is used to freeze-dry products such as biologicals, bacterial cultures, analytical chemistry moieties, and therapeutic molecules (e.g., antibodies, vaccines, drugs, and heat-sensitive proteins). ...
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Developing recombinant protein pharmaceuticals has proved to be very challenging because of both the complexity of protein production and purification, and the limited physical and chemical stability of proteins. To overcome the instability barrier, proteins often have to be made into solid forms to achieve an acceptable shelf life as pharmaceutical products. The most commonly used method for p...
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The growth curves of strains belonging to genera Candida and Saccharomyces grown through surfaced and submerged cultivation and their survival after lyophilization have been studied. Conclusions of practical importance have been drawn. It was found out that three-day-old cultures cultivated in solid medium possessed maximal resistance to freeze-drying. Nevertheless the cultures obtained by subm...
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Abstract—Lyophilization, also called freeze-drying, is an important dehydration technique mainly used for pharmaceuticals. Food industry also uses lyophilization when it is important to retain most of the nutritional quality, taste, shape and size of dried products and to extend their shelf life. Vacuum-Induced during freezing cycle (VI) has been used in order to control ice nucleation and, con...
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